轴突损伤及修复在神经退行性疾病中的研究进展
Progress in the study of axonal damage and repairment in neurodegenerative diseases
唐梓杨 1王岚淇 1廖疏影 1许寒冰 1石迪 1梅宇飞2
作者信息
- 1. 武汉科技大学脑科学先进技术学院,武汉 430065
- 2. 武汉科技大学脑科学先进技术学院,武汉 430065;职业危害识别与控制湖北省重点实验室,武汉 430065
- 折叠
摘要
随着老龄化社会快速到来,衰老相关的神经退行性疾病如阿尔茨海默病(Alzheimer's disease,AD)、帕金森病(Parkinson's disease,PD)、肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)等发病率日益升高,给社会和家庭带来巨大经济负担.轴突损伤是AD、PD和ALS的共有病理特征,不同疾病轴突损伤机制虽各不相同却又相互联系,修复轴突损伤已成为治疗衰老相关的神经退行性疾病的重要路径之一.本文总结和归纳了 AD、PD和ALS中神经元轴突损伤机制及修复方法相关研究进展,以期为早期防治衰老相关的神经退行性疾病提供新的靶点和思路.
Abstract
With the rapid arrival of the aging society,increasing incidence of Alzheimer's disease(AD),Parkinson's disease(PD)and amyotrophic lateral sclerosis(ALS)has brought great economic burden to the society and families.Axonal damage is a common pathological feature of AD,PD and ALS.Though the mechanisms of axonal damage are different,evidences indicate that pathomechanism of these diseases are interrelated,thus repairing axonal damage has become one of the important pathways for the treatment of age-related neurodegenerative diseases.In this paper,we summarize the research progress in the mechanisms of axonal damage and the related repairment in AD,PD and ALS,aiming to provide new targets and ideas for the prevention and treatment of aging-related neurodegenerative diseases in the early stage.
关键词
阿尔茨海默病/帕金森病/肌萎缩侧索硬化症/轴突Key words
Alzheimer's disease/Parkinson's disease/amyotrophic lateral sclerosis/axon引用本文复制引用
基金项目
武汉科技大学大学生创新创业训练计划(22Z106)
国家自然科学基金青年基金(82201351)
出版年
2024
NETL
NSTL
万方数据