Progress in the study of axonal damage and repairment in neurodegenerative diseases
With the rapid arrival of the aging society,increasing incidence of Alzheimer's disease(AD),Parkinson's disease(PD)and amyotrophic lateral sclerosis(ALS)has brought great economic burden to the society and families.Axonal damage is a common pathological feature of AD,PD and ALS.Though the mechanisms of axonal damage are different,evidences indicate that pathomechanism of these diseases are interrelated,thus repairing axonal damage has become one of the important pathways for the treatment of age-related neurodegenerative diseases.In this paper,we summarize the research progress in the mechanisms of axonal damage and the related repairment in AD,PD and ALS,aiming to provide new targets and ideas for the prevention and treatment of aging-related neurodegenerative diseases in the early stage.
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