Research progress of ubiquitin ligases and deubiquitinating enzymes in Alzheimer's disease
Alzheimer's disease(AD)is a common degenerative disease of the central nervous system in the elderly.Abnormal process in ubiquitination and deubiquitination leading to abnormal protein aggregation is a major cause of the development of AD.E3 ubiquitin ligases(E3s)regulate the ubiquitination of substrate proteins,promote the clearance of amyloid-β and Tau proteins,and improve synaptic and neuronal functions.Deubiquitinating enzymes(DUBs)remove the ubiquitination modification of substrate proteins,inhibit the degradation of amyloid-β and Tau proteins,and cause neuroinflammation.Since E3s and DUBs do not promote or inhibit the development of AD through a single pathway,this paper reviews the latest research progress on the mechanism of E3s and DUBs in AD,using the subfamilies to which they belong as an entry point.
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