Non-coding RNAs affect the biological behaviors of non-small cell lung cancer by regulating the Notch signaling pathway
Notch signaling pathway is one of the important pathways determining cell fate and has been widely studied and confirmed to play pivotal roles in proliferation,differentiation and apoptosis of non-small cell lung cancer(NSCLC).In the study of Notch signaling pathway and NSCLC,the regulation of Notch pathway by non-coding RNAs(ncRNAs)has become a research hotspot in the last five years,among which microRNAs(miRNAs),long chain non-coding RNAs(lncRNAs)and circular RNAs(circRNAs)can affect the progression of NSCLC by regulating the Notch pathway in various ways.In addition,the regulation of Notch pathway by ncRNAs is also associated with drug resistance in NSCLC.Although there are fewer studies on ncRNAs in NSCLC treatment,ncRNA-based targeted drugs will provide new options for NSCLC treatment.
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