Leptin-adiponectin ratio:a reliable indicator in metabolic health
The leptin-adiponectin ratio(LAR)integrates the contrasting roles of leptin and adiponectin in metabolic health,combining the pro-inflammatory and insulin-resistance properties of leptin with the anti-inflammatory and insulin-sensitizing characteristics of adiponectin.This offers a comprehensive and reliable indicator for assessing insulin sensitivity,adipose tissue dysfunction,and cardiovascular health.In clinical applications,LAR has demonstrated potential in diagnosing and evaluating a range of metabolic disorders,including insulin resistance,metabolic syndrome,and cardiovascular diseases,across diverse age groups from children to the elderly,and in special physiological conditions such as pregnancy.This paper provides robust evidence supporting LAR as an emerging biomarker in metabolic health assessment and discusses its current challenges and limitations,aiming to establish a scientific basis for disease status assessment,progression monitoring,efficacy observation,and clinical prognosis determination.
leptinadiponectinleptin-adiponectin ratioinsulin resistanceadipose tissue dysfunctionmetabolic health
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