Nrf2调控的铁死亡通路在有氧运动预防肌少症中的研究进展
Research progress on the Nrf2-regulated ferroptosis pathway in the prevention of sarcopenia by aerobic exercise
温小龙 1刘玉倩 2郭文闪 3翁锡全 4王海涛2
作者信息
- 1. 广州体育学院研究生院,广州 510500;岭南师范学院运动与健康研究所,湛江 524048
- 2. 岭南师范学院运动与健康研究所,湛江 524048
- 3. 华南师范大学体育科学学院,广州 510006
- 4. 广州体育学院运动与健康学院,广州 510500
- 折叠
摘要
肌少症作为一种与增龄性衰老相关的骨骼肌疾病,伴随着骨骼肌质量、力量、功能的下降.全球目前有超过5 000万肌少症患者,随着全球老龄化加剧,肌少症发生率会持续增加.研究表明,以脂质过氧化反应为主要生化特征的铁死亡与肌少症的发生相关.运动干预是目前防治肌少症的有效手段,其可能机制为核因子E2相关因子2(Nrf2)通过调控铁代谢相关蛋白表达而影响机体铁水平,避免铁死亡.该文通过梳理国内外相关研究,探讨肌少症与铁死亡的关系以及有氧运动对Nrf2调控的铁代谢及肌少症的影响,以期为预防和治疗肌少症提供新的作用靶点和理论依据.
Abstract
As a skeletal muscle disease associated with aging,sarcopenia is accompanied by a decline in skeletal muscle mass,strength,and function.More than 50 million people worldwide suffer from sarcopenia,and the incidence of sarcopenia will continue to increase as the world ages.Recent studies have shown that ferroptosis with lipid peroxidation as the main biochemical characteristic is related to the occurrence of sarcopenia.Exercise intervention is currently an effective means of combating sarcopenia,and the possible mechanism is that nuclear factor E2-related factor 2(Nrf2)affects the body's iron level by regulating the expression of proteins related to iron metabolism,thus avoiding ferroptosis.In this review,we based on relevant domestic and foreign studies explore the relationship between sarcopenia and ferroptosis,the effects of aerobic exercise on iron metabolism and sarcopenia regulated by Nrf2,with the aim of providing new targets and theoretical basis for the prevention and treatment of sarcopenia.
关键词
有氧运动/肌少症/核因子E2相关因子2/谷胱甘肽过氧化物酶4/铁死亡Key words
aerobic exercise/sarcopenia/Nrf2/GPX4/ferroptosis引用本文复制引用
基金项目
岭南师范学院人才专项(ZL2008)
岭南师范学院人才专项(ZL2009)
湛江市科技局项目(2022B01077)
湛江市科技局项目(2023B01168)
出版年
2024
NETL
NSTL
万方数据