Research progress on the Nrf2-regulated ferroptosis pathway in the prevention of sarcopenia by aerobic exercise
As a skeletal muscle disease associated with aging,sarcopenia is accompanied by a decline in skeletal muscle mass,strength,and function.More than 50 million people worldwide suffer from sarcopenia,and the incidence of sarcopenia will continue to increase as the world ages.Recent studies have shown that ferroptosis with lipid peroxidation as the main biochemical characteristic is related to the occurrence of sarcopenia.Exercise intervention is currently an effective means of combating sarcopenia,and the possible mechanism is that nuclear factor E2-related factor 2(Nrf2)affects the body's iron level by regulating the expression of proteins related to iron metabolism,thus avoiding ferroptosis.In this review,we based on relevant domestic and foreign studies explore the relationship between sarcopenia and ferroptosis,the effects of aerobic exercise on iron metabolism and sarcopenia regulated by Nrf2,with the aim of providing new targets and theoretical basis for the prevention and treatment of sarcopenia.
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