SIRT家族介导热量限制调控心血管疾病
Research progress on caloric restriction mediating the regulation of cardiovascular diseases by the SIRT family
张慧 1李婷婷 1张铭宸 1杜锦超 1王孝文 1孙忠广1
作者信息
摘要
心血管疾病是全球致死率最高的疾病,短期和长期热量限制(caloric restriction,CR)均能够降低心血管疾病的发生率.SIRT家族参与细胞内多种代谢,在减轻心脏炎症、氧化应激以及线粒体功能调节上起关键作用.该文就SIRT家族在CR改善各类心血管疾病中的作用和机制进行综述,并概述了热量限制模拟物通过SIRT途径对心血管疾病的改善作用,为心血管疾病的早期防治和康复提供参考.
Abstract
Cardiovascular disease is the disease with the highest mortality rate in the world.Both short-term and long-term caloric restriction(CR)can reduce the incidence of cardiovascular disease.The SIRT family is involved in various intracellular metabolisms and plays a key role in reducing cardiac inflammation,oxidative stress and regulating mitochondrial function.This article reviews the role and mechanism of the SIRT family in the improvement of various cardiovascular diseases by CR,and outlines the improvement effect of caloric restriction mimetics on cardiovascular diseases through the SIRT pathway,providing a reference for the early prevention,treatment and rehabilitation of cardiovascular diseases.
关键词
SIRT/热量限制/热量限制模拟物/心血管疾病Key words
SIRT/caloric restriction/caloric restriction mimetic/cardiovascular disease引用本文复制引用
基金项目
山东省自然科学基金青年基金(ZR2022-QH094)
国家食品安全风险评估中心科研联合攻关计划(LH2022GG11)
山东省教育厅项目(SDYAL2022154)
山东省中医药科技项目(2021)(2021M155)
出版年
2024
NETL
NSTL
万方数据