Progress in the development of antitumor drugs targeting glycosylation modifications
Glycosylation,a ubiquitous biochemical process occurring both intracellularly and extracellularly,is crucial for the normal functioning of organisms,while its abnormal changes are often closely associated with the development of various diseases.In the field of oncology,glycosylation not only affects the proliferation,migration,and invasive capabilities of tumor cells,but is also significantly linked to immune evasion in cancer.Currently,targeted cancer therapies focusing on glycosylation-related processes are becoming a new research focus.This paper will review the development of targeted cancer drugs related to glycosylation processes from three aspects:tumor-associated carbohydrate antigens,lectins,and glycosyltransferases.
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