Molecular function and related disease of the Tectonic protein family
Tectonic(TCTN),derived from ancient Greek,means construction,indicating its important role in constructing cellular function.There are generally 1～3 protein members of this family in the model organisms for ciliary research including human.The TCTN protein family is located at the ciliary base called the transition zone,constructing a ciliary gate responsible for components sorting between the cytoplasm and cilia,and regulating the ciliary functions.In addition,cellular development could also be regulated by TCTN proteins via the Hedgehog signaling pathway and cell cycle.Mutations in TCTN family genes often lead to ciliopathies,and abnormal expression of TCTN is associated with the progression of cancer,making it a potential target for tumor treatment.In this review,we discuss and summarize the molecular functions and related diseases of the TCTN family,providing theoretical reference and guidance for understanding,preventing,and treating ciliopathies and related tumors caused by TCTN mutations.
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