Tectonic蛋白家族的分子功能与相关疾病的研究进展
Molecular function and related disease of the Tectonic protein family
蒋林 1郁慧敏 1徐闯 1李亚 1王亮1
作者信息
- 1. 江苏师范大学生命学学院,徐州 221116
- 折叠
摘要
Tectonic(TCTN),源于古希腊语,意为构造,表明该蛋白对细胞功能的重要构建作用.在人类和纤毛研究的模式生物中,该家族蛋白成员一般有1～3个.TCTN蛋白家族定位在细胞纤毛的基部过渡区,构建了纤毛基部"门"结构,负责胞质与纤毛间的物质分选,调控纤毛功能.此外,其还可通过调控Hedgehog信号通路和细胞周期等,介导细胞发育.TCTN家族基因突变常导致纤毛病发生,并且异常表达与癌症的进展相关,可作为肿瘤治疗的潜在靶标.本文主要对TCTN蛋白家族的分子功能和相关疾病进行分析与总结,为理解、预防、治疗TCTN突变导致的纤毛病和相关肿瘤提供理论参考及指导.
Abstract
Tectonic(TCTN),derived from ancient Greek,means construction,indicating its important role in constructing cellular function.There are generally 1～3 protein members of this family in the model organisms for ciliary research including human.The TCTN protein family is located at the ciliary base called the transition zone,constructing a ciliary gate responsible for components sorting between the cytoplasm and cilia,and regulating the ciliary functions.In addition,cellular development could also be regulated by TCTN proteins via the Hedgehog signaling pathway and cell cycle.Mutations in TCTN family genes often lead to ciliopathies,and abnormal expression of TCTN is associated with the progression of cancer,making it a potential target for tumor treatment.In this review,we discuss and summarize the molecular functions and related diseases of the TCTN family,providing theoretical reference and guidance for understanding,preventing,and treating ciliopathies and related tumors caused by TCTN mutations.
关键词
Tectonic/纤毛/纤毛过渡区/纤毛病/Hedgehog信号通路/细胞周期Key words
Tectonic/cilia/ciliary transition zone/ciliopathies/Hedgehog signaling pathway/cell cycle引用本文复制引用
基金项目
江苏省自然科学基金面上项目(BK2023-1351)
徐州市重点研发计划(社会发展)项目(KC-23300)
江苏高校优势学科建设工程资助项目(PAPD)()
出版年
2024
NETL
NSTL
万方数据