Research progress on the role of endocannabinoids system in exercise induced prevention and treatment of Alzheimer's disease
Alzheimer's disease(AD)has become a weighty public health problem.The endocannabinoids system(ECS)is a powerful signal transduction system.It has been shown that the ECS is involved in almost all physiological functions of the nervous system and is closely related to the development of AD.Thus,the ECS is regarded as a potential intervention target for AD prevention and treatment.A large number of studies have shown that the appropriate physical exercise can reduce the probability of AD in high-risk population,effectively improve or alleviate AD induced dysfunction of the central nervous system.Previous studies demonstrated that exercise might decrease inflammation,enhance synaptic plasticity and increase neurogenesis by regulating the ECS in AD brain.Based on related studies,this review focuses on the role of ECS in exercise-induced prevention and protection against AD.
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