Study on the relationship of aging and ionizing radiation injury
Aging is a normal life phenomenon in the human body,and its process is accompanied by a decline in the function of many organs and systems,which in turn causes the occurrence of related diseases.Cellular senescence,as one of the key factors of aging,is of great significance in the aging process.With the continuous progress of science and technology,medical imaging has become the world's largest source of man-made radiation.Radiation therapy,as one of the adjuvant treatments for malignant tumors,kills tumor cells while causing damage to normal organs and tissues.Ionizing radiation alters the cellular state by inducing DNA damage,leading to cell necrosis,apoptosis or senescence.Thus,senescence establishes a link with ionizing radiation damage.This review focuses on the relationship between individual senescence and cellular senescence and radiation injury,summarizes the relevant mechanisms of senescence and radiation damage in different tissues and organs,and aims to lay the foundation for future related studies to facilitate a full understanding of the mechanisms of radiation injury in the aging population.
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