Research progress on branched-chain amino acid metabolism in cancer
The abnormal metabolism of branched-chain amino acids(BCAAs)in cancer has attracted lots of attention.BCAAs include leucine,isoleucine and valine,which are not only fundamental protein constituents,but also play critical roles in cancer progression.Numerous studies have found that the metabolic enzymes and metabolites in the BCAAs metabolic pathway play regulatory roles in tumorigenesis and development,and influence tumor epigenetic modification and immune response.Although some original research papers on the regulation of tumors by BCAAs and their metabolites have been published,a systematic review is lacking.Therefore,this review discusses the regulatory mechanisms of BCAA metabolism in cancer cells and how it affects tumor progression,providing a theoretical basis for further development of combined tumor-targeted therapies.
NETL
NSTL
万方数据
