运动调节Hippo-YAP通路改善心力衰竭的分子机制研究进展
Progress in the molecular mechanism of exercise modulation of the Hippo-YAP pathway to ameliorate heart failure
鞠文宇 1陈志欣 1张嘉敏 1王友华1
作者信息
- 1. 陕西师范大学体育学院,西安 710119
- 折叠
摘要
心力衰竭是严重影响全球生命健康的疾病之一,其病理发生发展过程与炎症浸润、能量代谢紊乱和线粒体功能障碍密切相关.Hippo-YAP通路具有感知机械压力刺激,从而调控细胞增殖、分化和器官大小的生物学功能.运动作为一种简单易行且无副作用的非药物治疗手段,在调控免疫炎症反应和线粒体质量控制等方面发挥重要作用,有效抑制心力衰竭病理发展;研究发现,运动可能通过调节Hippo-YAP通路来改善心力衰竭.该文综述了 Hippo-YAP通路与心力衰竭发生发展的生物学机制,进一步论述了运动调节Hippo-YAP通路改善心力衰竭的分子机制,以期为预防和治疗心力衰竭提供新思路和理论依据.
Abstract
Heart failure is one of the most important diseases affecting global life and health.Its pathogenesis is closely related to the disorder of inflammatory infiltration,energy metabolism and mitochondrial function.The Hippo-YAP pathway has the biological function of sensing mechanical pressure to regulate cell proliferation and differentiation and organ size.Exercise,as a simple and easy non-pharmacological treatment without side effects,plays an important role in modulating immune-inflammatory responses and mitochondrial quality control,and effectively inhibits the development of heart failure pathology.It has been found that exercise may ameliorate heart failure by modulating the Hippo-YAP pathway.This paper reviews the biological mechanism of the Hippo-YAP pathway and the development of heart failure,and further discusses the molecular mechanism by which exercise regulates the Hippo-YAP pathway to improve heart failure,in order to provide new ideas and theoretical basis for the prevention and treatment of heart failure.
关键词
Hippo-YAP通路/心力衰竭/运动Key words
Hippo-YAP pathway/heart failure/exercise引用本文复制引用
基金项目
国家自然科学基金项目(81570449)
2023年大学生创新创业项目(S202310718159)
2023年大学生创新创业项目(S202310718175)
2023年大学生创新创业项目(S202310718195)
陕西师范大学青年学者培育项目(2022-BA001)
出版年
2024
NETL
NSTL
万方数据