Progress in the molecular mechanism of exercise modulation of the Hippo-YAP pathway to ameliorate heart failure
Heart failure is one of the most important diseases affecting global life and health.Its pathogenesis is closely related to the disorder of inflammatory infiltration,energy metabolism and mitochondrial function.The Hippo-YAP pathway has the biological function of sensing mechanical pressure to regulate cell proliferation and differentiation and organ size.Exercise,as a simple and easy non-pharmacological treatment without side effects,plays an important role in modulating immune-inflammatory responses and mitochondrial quality control,and effectively inhibits the development of heart failure pathology.It has been found that exercise may ameliorate heart failure by modulating the Hippo-YAP pathway.This paper reviews the biological mechanism of the Hippo-YAP pathway and the development of heart failure,and further discusses the molecular mechanism by which exercise regulates the Hippo-YAP pathway to improve heart failure,in order to provide new ideas and theoretical basis for the prevention and treatment of heart failure.
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