Heart failure is one of the most important diseases affecting global life and health.Its pathogenesis is closely related to the disorder of inflammatory infiltration,energy metabolism and mitochondrial function.The Hippo-YAP pathway has the biological function of sensing mechanical pressure to regulate cell proliferation and differentiation and organ size.Exercise,as a simple and easy non-pharmacological treatment without side effects,plays an important role in modulating immune-inflammatory responses and mitochondrial quality control,and effectively inhibits the development of heart failure pathology.It has been found that exercise may ameliorate heart failure by modulating the Hippo-YAP pathway.This paper reviews the biological mechanism of the Hippo-YAP pathway and the development of heart failure,and further discusses the molecular mechanism by which exercise regulates the Hippo-YAP pathway to improve heart failure,in order to provide new ideas and theoretical basis for the prevention and treatment of heart failure.
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