LncRNA在炎症性肠病中的作用及植物化学物干预的研究进展
The research progress of lncRNA in inflammatory bowel disease and phytochemical intervention
陈梦圆 1蒋晓欣 1任静宜 1田志超 1何灿霞1
作者信息
- 1. 宁波大学医学部公共卫生学院,宁波 315211
- 折叠
摘要
炎症性肠病(inflammatory bowel diseases,IBD)是一种慢性、复发性胃肠道疾病,包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD)两种类型.研究表明,以长链非编码RNA(long non-coding RNA,lncRNA)为代表的表观遗传因素在IBD发病中具有重要作用.植物化学物是从天然植物中分离提取的非传统营养素成分,具有易得、低毒等特点.多种植物化学物已被证实在炎症性肠病中具有保护作用.该文就IBD发病机制及lncRNA参与调控IBD的研究进展进行系统论述,并探讨植物化学物抑制IBD的可能机制,以期为植物化学物靶向lncRNA改善IBD提供理论依据.
Abstract
Inflammatory bowel diseases(IBD)are chronic,relapsing disorders of the gastrointestinal tract,which are represented mainly by ulcerative colitis(UC)and Crohn's disease(CD).Studies have shown that epigenetic factors represented by long non-coding RNA(lncRNA)play an important role in the pathogenesis of IBD.Phytochemicals are non-traditional nutrient components isolated and extracted from natural plants,characterized by easy availability and low toxicity.Some phytochemicals have been identified to have a protective role in IBD.In this paper,we systematically discuss the pathogenesis of IBD and the progress of research on the role of lncRNA in the regulation of IBD,and explore the possible mechanisms of phytochemicals inhibiting IBD,and thus providing theoretical basis for phytochemicals in the improvement of IBD by targeting lncRNA.
关键词
炎症性肠病/lncRNA/植物化学物Key words
inflammatory bowel diseases/long non-coding RNA/phytochemicals引用本文复制引用
基金项目
国家自然科学基金项目(82103819)
宁波市自然科学基金项目(2022J237)
出版年
2024
NETL
NSTL
万方数据