Implications and mechanisms of O-GlcNAcylation on anti-cancer therapy efficacy
O-linked β-N-acetylglucosamine(O-GlcNAcylation)is one of the protein translation modifications(PTMs)that regulate a variety of fundamental cellular biological processes,including gene transcription,signal transduction,stress response and cell metabolism.The role of dysregulated O-GlcNAcylation in tumorigenesis has been recognized,but its role in the anti-cancer therapy efficacy has not been elucidated.Therefore,this article reviews the latest evidence that dysregulated O-GlcNAcylation affects anti-cancer therapy efficacy,analyzes several possible mechanisms by which dysregulated O-GlcNAcylation levels affect anti-cancer therapy efficacy,and discusses the possibility of targeting O-GlcNAcylation as a cancer therapeutic sensitizer,aiming to provide theoretical references to improve the efficacy of anti-cancer therapy.
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