Research progress in exosomal miRNAs regulating preeclampsia
Preeclampsia is an idiopathic hypertensive syndrome that develops after 20 weeks gestation,and characterized by primary hypertension and proteinuria.It affects approximately 3％to 5％of pregnant women worldwide and is the leading cause of maternal and perinatal death.Exosomes are vesicle-like bodies secreted by cells,with a diameter of 30～1 50 nm and a typical lipid bilayer membrane structure.Exosomes contain biological information specific to mother cells,such as protein,mRNA,microRNA,and mediate a variety of physiological and pathological processes.Due to the influence of genetic or environmental factors,the concentration of exosomes and exosomal miRNAs derived from placenta tissue or maternal are significantly changed in patients with preeclampsia.Exosomal miRNAs can regulate the trophoblastic function,angiogenesis,maternal and fetal immunity and inflammatory response,and participate in the regulation of the occurrence and development of preeclampsia.This article reviews the research progress of exosomal miRNAs in the regulation of preeclampsia.
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