CMKLR1与抑郁障碍相关的研究进展
Research progress on the association between CMKLR1 and depression
唐思嘉 1陈俊 1方贻儒2
作者信息
- 1. 上海交通大学医学院附属精神卫生中心临床研究中心,上海 200032
- 2. 上海交通大学医学院附属瑞金医院精神心理科&情感障碍中心,上海 200025;上海交通大学医学院附属精神卫生中心临床研究中心,上海 200032
- 折叠
摘要
抑郁障碍作为一种广泛影响全球人口的心理健康问题,引起了研究人员对其潜在生物学基础的兴趣.近年来,神经递质、神经回路和免疫系统在抑郁障碍中的作用研究不断增多.在这一背景下,CMKLR1(chemokine-like receptor 1)作为一个新兴的研究方向引起了研究人员的关注.CMKLR1最初被认为在免疫系统中发挥重要作用,然而最近的研究表明,它也可能与神经炎症的调节密切相关.本综述旨在深入探讨CMKLR1与抑郁障碍之间的潜在关联,揭示其在疾病发生和发展中的可能机制,以及作为潜在治疗靶点的可能性.
Abstract
Depression,as a widespread mental health issue affecting the global population,has sparked interest among researchers in understanding its potential biological basis.In recent years,there has been a growing body of research on the roles of neurotransmitters,neural circuits,and the immune system in depression.Against this backdrop,CMKLR1(chemokine-like receptor 1)emerged as a novel research focus.It was initially thought to play a crucial role in the immune system,but recent studies suggested a potential close connection between CMKLR1 and the regulation of neuroinflammation.This review aims to delve into the potential association between CMKLR1 and depression,uncovering its possible mechanisms in the onset and development of the disorder,as well as its potential as a therapeutic target.
关键词
CMKLR1/抑郁障碍/神经炎症/小胶质细胞Key words
CMKLR1/depression/neuroinflammation/microglia引用本文复制引用
出版年
2024
NETL
NSTL
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