Research progress on the mechanism of viral endocytosis mediated by caveolae/caveolin
Caveolae is a polymorphic membrane invagination structure on plasma membrane,which is widely distributed in mammalian cells.Caveolin-1(Cav-1)plays a major role in the structure of caveolae.In addition to some biological processes,such as mechanical protection,regulation of lipid homeostasis and transport,vesicle transport,and signal transduction,caveolae/caveolin is also involved in the occurrences of many diseases,such as tumors,cardiovascular diseases,and diabetes.Accumulating evidences have shown that caveolae/caveolin participates in viral infection processes,especially mediating viral invasion into host cells.But the molecular mechanism of caveolin in viral invasion is still unclear,which is still a hotspot in antiviral research.Based on that,our paper reviews the research on the structure and function of caveolae/caveolin,and its regulatory mechanism on viral endocytosis,so as to provide a theoretical basis for further elucidating the molecular mechanism of caveolae-mediated viral endocytosis and developing new drugs for early stage of viral infection.
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