The mechanism of CD8+T cell exhaustion in hepatocellular carcinoma
Under continuous antigen stimulation in hepatocellular carcinoma,CD8+T cells undergo an exhausted state through various mechanisms,which is characterized by sustained upregulation and co-expression of inhibitory receptors on the surface of CD8+T cells,as well as changes in epigenetic and transcriptional profiles,and metabolic disorders.These factors cause impaired proliferation function of CD8+T cells,progressive loss of immune function,and ultimately CD8+T cell death,resulting in immune escape of tumor cells.This article provides a review of the latest research progress on the occurrence,development,characteristics,and potential mechanisms of CD8+T cell exhaustion in hepatocellular carcinoma.It aims to serve as a reference for further mechanism research and targeted treatment of CD8+T cell exhaustion in hepatocellular carcinoma.
NETL
NSTL
万方数据
