TBC proteins,as Tre2-Bub2-Cdcl6(TBC)structural domain-containing GTPase activators,play a key role in the negative regulation of Rab proteins.This structural domain integrates the Tre2 proto-oncogene,the Bub2 yeast cell cycle regulatory protein,and the Cdc16 cell division cycle gene,showing a high degree of evolutionary conservation.By regulating the GTP-GDP transition cycle of Rab proteins,the TBC proteins play an important role in specific intracellular transport.It is not only essential in maintaining normal cellular physiological processes,but also its abnormal function or mutation is closely associated with the development of several human diseases.In this paper,we review the latest research results on the structural features,biochemical functions and roles of TBC proteins in human diseases,aiming to gain a deeper understanding of their potential mechanisms in disease development.
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