Research progress of orexin system in mood disorders
Mood disorders include post-traumatic stress disorder,depression,anxiety and so on.In recent years,the incidence of mood disorders has shown a significant upward trend.At present,the effect of drug treatment for mood disorder is not good,and there are many side effects.Orexin is involved in the regulation of leaming and memory,sleep-arousal and emotions by acting on orexin receptors.With the in-depth study of orexin receptor antagonists in the treatment of insomnia,it has been found that these drugs not only have the potential to improve insomnia,but also begin to attract widespread attention in mood regulation.The purpose of this review is to systematically summarize the research progress and mechanism of the orexin system in mood disorders by combing and summarizing recent animal experiments and some clinical trials.
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