Biological mechanisms of DNA methylation of brain specific genes in anxiety disorders
Anxiety disorder is a common mental disorder.DNA methylation is a key epigenetic mechanism in the development of anxiety disorders,which can alter genetic expression without altering the DNA sequence and binds a methyl group to the cytosine 5 carbon of CpG dinucleotide through the action of DNA methyltransferase,thereby inhibiting gene transcription,affecting chromatin structure,and regulating histone modification in ways to affect gene expression.Animal models of anxiety disorders involve mechanisms by which altered levels of DNA methylation in relevant brain regions affect gene expression and regulate neurotransmitters.The mechanism of action of DNA methylation in anxiety is not fully understood.This paper focuses on the relationship between DNA methylation of brain specific genes,such as glucocorticoid receptor(GR),brain-derived neurotrophic factor(BDNF)and 5-hydroxytryptamine(5-HT)related gene and anxiety disorders,and summarizes the research and puts forward corresponding opinions,aiming at providing theoretical basis for the prevention and treatment of anxiety disorders.
NETL
NSTL
万方数据
