Optimization of human induced pluripotent stem cell-derived microglia-like cell model and its application in the study of Alzheimer's disease
Over the past two decades,human induced pluripotent stem cells have been widely used for in vitro studies of human neurodevelopmental mechanisms,disease modeling,and drug discovery,especially in the field of neurodegenerative diseases.Compared to other research models,in vitro models based on induced pluripotent stem cell-induced microglia-like cells are more favorable for studying the pathological mechanisms behind Alzheimer's disease.However,induced multifunctional stem cells from different sources vary widely in differentiation potential and epigenetic status,and their in vitro differentiation ability is susceptible to reprogramming methods and culture systems.Therefore,this paper reviews the current development of microglia-like cell models derived from human induced pluripotent stem cells and their applications in Alzheimer's disease research in recent years,hoping to provide an effective reference for future microglia research.
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