蛋白微阵列芯片技术和产业化发展前景及存在问题
Prospects and bottlenecks in development and industrialization of protein biochips
杜卫东1
作者信息
- 1. 安徽医科大学基础医学院病理学教研室,合肥 230032
- 折叠
摘要
生物微阵列芯片技术发展日新月异.与基因芯片不同,受蛋白质立体结构、生物学活性、固相载体表面化学修饰物稳定性及检测与分析方法学等方面的影响,蛋白芯片研发及产业化道路曲折艰辛.本文就蛋白微阵列芯片类型、表面化学修饰、芯片研发现状、桎梏及发展趋势作一简要综述.
Abstract
Development of biochip technology remains a great challenge.Unlike gene biochip,the research and development and industrialization of protein biochip yet runs on a way covered with thorns as a result of influence by intrinsic three-dimensional construction and sustainable biological activity of on-chip proteins,stabilization of surface chemical modification on solid supports and methodology of detection and analysis.In this review,we have a brief review on types of protein biochips,surface chemical modification,manufacturing processes,and current R&D status,main shackles and potential trends in biochip research and development.
关键词
生物芯片/蛋白质/生物技术/检测平台/临床应用Key words
biochip/protein/biotechnology/assay platform/clinical application引用本文复制引用
基金项目
国家自然科学基金面上项目(30470591)
国家自然科学基金面上项目(81171655)
安徽省自然科学基金面上项目(050430716)
安徽省自然科学基金面上项目(090413114)
安徽省国际科技合作项目(1403062023)
安徽省转化医学研究院科研基金(2017zhyx37)
出版年
2024
NETL
NSTL
万方数据