Progress in the regulation of cell ferroptosis through members of the CNC-bZIP transcription factor family
Ferroptosis is iron-dependent programmed cell death by membrane lipid peroxidation,and targeting ferroptosis has emerged as a potential therapeutic approach for a variety of diseases,including cancer and neurodegenerative pathologies.Ferroptosis is mainly regulated by antioxidant and iron transport systems,such as cystine/glutamate reverse transporter proteins,glutathione peroxidase and iron transporter proteins,with dysregulation or dysfunction of antioxidant systems thought to be an important factor in the induction of ferroptosis.Members of the CNC-bZIP transcription factor family play important sensing and regulatory roles in organismal redox homeostasis,protein homeostasis and glycolipid metabolism homeostasis,and are involved in the process of cellular ferroptosis by regulating redox homeostasis and iron metabolism homeostasis.In this paper,the specific roles of CNC-bZIP transcription factors,such as NFE2L1,NFE2L2 and NFE2L3,in regulating the process of cellular ferroptosis are elaborated in detail,and the similarities and differences in the molecular mechanisms of cellular ferroptosis regulated by CNC-bZIP transcription factors are systematically sorted out to provide molecular targets and theoretical references for targeting redox homeostasis to prevent and control cellular ferroptosis-related diseases.
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