Integration of synthetic biology and nanobiotechnology for the application of bacterial cancer therapy
Bacterial cancer therapy has a long history,but the biosafety and tumor targeting are relatively low,which leads to unsatisfactory therapeutic effects.In recent years,the development of synthetic biology and nanobiotechnology has given new hope to bacterial cancer therapy.Synthetic gene circuits helps to reshape bacterial structures,reduce toxicity and enhance targeting,while nanotechnology can facilitate gene delivery and participate in mediating gene regulation.The integration of synthetic biology and nanobiotechnology can construct nano-scale functional modules and nano-artificial hybrid system,and enhance the function of the modified system.It will help to solve the problems of bacterial cancer therapy and promote clinical transformation.In this review,we focus on the recent research progress in the integration of synthetic biology and nanobiotechnology and their application in bacterial cancer therapy.Three aspects are included:the promotion of synthetic biology in the development of tumor bacterial therapy,the integration of synthetic biology and nanobiotechnology,and the application of such integration in tumor bacterial therapy.Furthermore,the recent research work in this field is discussed,and the application and prospect of related technologies in bacterial cancer therapy are analyzed and prospected.
synthetic biologynanotechnologybacterial cancer therapygenetic engineering
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维普
