Estrogen receptor-mediated transactivation in ovarian cancer
Estrogen receptor(ER)is a crucial member of the nuclear receptor superfamily,playing a significant role in modulating the expression of target gene that can be regulated by co-regulatory factors and non-coding RNAs.Numerous studies have revealed that ERs-mediated transactivation is associated with the development of epithelial ovarian cancer and ovarian granulosa cell tumor,especially endometrioid ovarian cancer.Our review aims to summarize the newly discovered roles of co-regulatory factors,non-coding RNAs and the target genes in ERs-mediated transactivation,as well as the involvement of ERs in the progression of endometriosis to endometriosis-associated ovarian cancer.We believe this will provide insight into understanding the pathogenesis of those ovarian cancers and developing novel endocrine therapy strategies.
estrogen receptorovarian cancermodulation of gene transcriptionco-regulator
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