The role of extracellular vesicles in neurodegenerative diseases
Neurodegenerative diseases(NDs)are characterized by progressive loss of neurons and abnormal accumulation and aggregation of disease-causing proteins in the brain,including Alzheimer's disease(AD),Parkinson's disease(PD),and amyotrophic lateral sclerosis(ALS).Early symptoms of NDs are not obvious for diagnosis,and effective biomarkers and therapeutic measures are lacking.Recent studies have shown that proteins associated with these diseases can be secreted and transferred between cells via extracellular vesicles(EVs).EVs are widely distributed in body fluids,which can cross various biological barriers such as the blood-brain barrier,and are considered as preferred biomarkers for diagnosis and prognosis.This paper briefly introduces the biogenesis and function of EVs,and discusses their role in NDs.
万方数据
维普
