The role of endoplasmic reticulum stress-related regulatory mechanisms in immune response and diseases
The endoplasmic reticulum(ER)takes part in the post-translational modification and folding of native protein.Due to the internal or external stimulations,the function of the endoplasmic reticulum can be interrupted to some degree,leading to serious impairment of protein processing and transportation.With the accumulation of the unfolded or misfolded proteins,ER can display some biological responses,termed as ER stress.If ER stress occurs,the unfolded protein response could be stimulated to recover the normal homeostasis of ER.When the stimulus persists or is too strong,it will trigger the autophagy pathway to degrade the protein,which in turn plays a role in maintaining homeostasis.In recent years,it has been found that the three related pathways of the unfolded protein response are not only closely related to the signaling pathways of the innate immune response,but also participate in the immune response by regulating immune cells.In addition,the regulation of these three pathways and their related factors is closely related to neurodegenerative diseases,metabolism-related diseases,liver diseases and so on.In this review,molecular mechanisms for ER stress will be summarized systematically to give new insights into therapy for diseases in future.
endoplasmic reticulum stressunfolded protein responsecell homeostasisimmune responsedisease
万方数据
维普
