Research progress of stress granule in cardiovascular and cerebrovascular diseases,tumor and neurodegenerative diseases
Protein synthesis is one of the most complex biological processes in eukaryotic cells.One important way that eukaryotes respond to environmental stresses is to delay protein synthesis,and the main regulatory center of this process is the stress granules,which include numerous translationally stalled mRNAs.Stress granules are dynamic,membrane-less cytoplasmic aggregates containing components including RNA-binding proteins,mRNA,and translation initiation factors,serving as crucial mechanisms for cell adaptive regulation.When cells are exposed to environmental stress,such as oxidative stress,heat shock,ultraviolet radiation,and viral infections,they respond by forming dynamic and reversible dense particles known as stress granules in the cytoplasm.These stress granules aim to reduce stress-related damage and promote cell survival.However,recent studies have shown that the formation of persistent and abnormal stress granules is related to the occurrence and development of various diseases.Although there are an increasing number of studies on the composition,formation and depolymerization of stress granules,their correlation with diseases and specific mechanisms remains unclear.Therefore,this paper reviews the relationships between stress granules and cardiovascular and cerebrovascular diseases,tumor and neurodegenerative diseases.
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