Research progress of SIRT6 in striated muscle metabolism and related diseases
Sirtuin6(SIRT6)is a chromatin-associated NAD+-dependent enzyme widely expressed in all mammalian tissues and plays a crucial role in maintaining life and health.As an important part of the human body,striated muscle(skeletal and cardiac muscle)assumes multiple functions such as energy metabolism,postural maintenance,and promotion of blood flow,and striated muscle is crucial in maintaining activities of the organisms.When striated muscle metabolism is disturbed,a series of disorders may be triggered,such as skeletal muscle atrophy and cardiac muscle hypertrophy.Recent studies have shown that SIRT6 is involved in the regulation of the biological functions of striated muscle.This review explores the mechanism of SIRT6 in the physiological and pathological states of striated muscle,aiming to provide new ideas and strategies for basic research and for disease prevention and treatment.
SIRT6striated muscleskeletal musclecardiac musclephysiological statepathological state
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