Research progress of cGP and IGF-1 in brain development and cognitive impairment
Insulin-like growth factor-1(IGF-1)is an endogenous growth factor and plays an important role in brain development and cognitive function.The change of IGF-1 with age is one of the key factors in the development of senile cognitive impairment.The reversible binding of IGF-1 to IGF-binding protein-3(IGFBP-3)regulates the amount of bioavailable and functional IGF-1 in circulation.Cyclic glycine-proline(cGP)is a metabolite of IGF-1,which can bind to IGFBP-3.CGP maintains its affinity to IGFBP-3 and competes with IGF-1 for IGFBP-3 binding.As a result,cGP and IGFBP-3 collectively regulate the function of circulating IGF-1.Clinical observations show that elderly individuals with higher cGP/IGF-1 molar ratios have better cognitive function.This article reviews the research progress of cGP and IGF-1 in brain development and senile cognitive impairment,hoping that the molar ratio of cGP/IGF-1 can be used as a new marker of cognitive impairment.
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