Research progress on the role of primary cilia in psychiatric disorders
Primary cilia(PC)are microtubule-based organelles present on the surface of most mammalian cells,primarily composed of the basal body,axoneme,ciliary membrane,and ciliary matrix.As crucial cellular signaling devices,PC in neural cells participate in regulating various physiological processes,including neural development,neuronal activity,sensory functions,and biological rhythm,and are closely associated with the pathogenesis of several psychiatric disorders.This article reviews the diverse physiological functions of PC in neural cells,particularly emphasizing their regulatory roles in the mature nervous system.It discusses the involvement of PC in the pathophysiology of sleep disorders,schizophrenia,autism spectrum disorders,anxiety disorder and depression disorder.This review provides new insights into the pathophysiological mechanisms of psychiatric disorders and holds promise for new approaches to the prevention,diagnosis,and treatment of these conditions.
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