The role of nuclear receptors in fetal-origin non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease(NAFLD)is one of the most commonly chronic liver diseases worldwide.It is characterized by hepatic steatosis,which may lead to more severe liver disease.A growing number of epidemiological and animal studies have demonstrated that NAFLD is a development-originated disease.Nuclear receptors(NRs)are known as transcription factors that regulate the expression of genes related to metabolism of fatty acid in the liver,responding to environment or hormonal signaling.Thereby,NRs participate in or interfere with the occurrence of NAFLD.Recent studies showed that adverse environment in the early life affects expression and function of the NRs,and epigenetic modifications participate in the continuous alteration of NRs expression or its downstream target genes.Therefore,NRs may be involved in the occurrence of fetal-origin NAFLD.The role of NRs in fetal-origin NAFLD was reviewed in this manuscript.
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