Research progress on senescent associated secretory phenotype in regulating bone tissue cells
With the aging population,osteoporosis has become one of the severe global public health issues.Osteoporosis is intimately tied to cellular aging,which in turn is accompanied by the emergence of the senescence-associated secretory phenotype(SASP).SASP,including various cytokines such as pro-inflammatory cytokines and chemokines,can accelerate cellular aging,affect the function of bone tissue cells,disrupt bone homeostasis,and expedite the process of bone aging.Recent studies have indicated that SASP may become a therapeutic target for bone diseases such as osteoporosis.However,the mechanisms by which SASP regulates bone tissue cells remain unclear.In light of this,this review summarizes the regulatory mechanisms of SASP in bone tissue cells,which can provide a theoretical foundation for the prevention and treatment of age-related bone diseases.
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