Interferon gamma(IFN-γ)is a cytokine with multiple biological effects,involved in innate and acquired immunity in vivo.Recent studies have found that IFN-γ is closely related to the pathophysiological process of cerebral ischemia.IFN-γ not only mediates inflammatory responses,damages the blood-brain barrier,promotes T cell and NK cell infiltration during the early stage of cerebral ischemia through various processes,but also play a neuroprotective role by promoting nerve regeneration and recruiting CD 169 macrophages to infiltrate the brain parenchyma during cerebral ischemic recovery.In addition,IFN-γ also plays a different role in cerebral ischemia complications:promoting the onset of early post-stroke depression and preventing stroke-associated pneumonia.This article focuses on the dual role of IFN-γ in cerebral ischemia and its clinical research progress to provide research basis for prevention and treatment of cerebral ischemia.
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