IFN-γ在脑缺血中的双重作用
The dual role of IFN-γ in cerebral ischemia
李米亚 1陈越 1兰平 1张文欣 1何治1
作者信息
- 1. 三峡大学国家中医药管理局中药药理科研三级实验室,宜昌 443002;三峡大学基础医学院,宜昌 443002
- 折叠
摘要
γ干扰素(interferon gamma,IFN-γ)是一种具有多种生物学效应的细胞因子,参与体内固有免疫和获得性免疫.近年研究发现IFN-γ与脑缺血的病理生理进程密切相关,IFN-γ不仅通过介导炎症反应损害血脑屏障促进脑缺血早期T细胞和NK细胞浸润等过程对脑缺血性疾病发挥神经损伤作用,也可通过促进神经再生和在脑缺血恢复期招募CD169巨噬细胞浸润脑实质等过程发挥神经保护作用.除此之外,IFN-γ在脑缺血并发症中也发挥不同作用:促进早期卒中后抑郁发病和预防卒中相关性肺炎.该文重点围绕IFN-γ在脑缺血中的双重作用及其临床研究进展进行综述,为防治脑缺血提供研究基础.
Abstract
Interferon gamma(IFN-γ)is a cytokine with multiple biological effects,involved in innate and acquired immunity in vivo.Recent studies have found that IFN-γ is closely related to the pathophysiological process of cerebral ischemia.IFN-γ not only mediates inflammatory responses,damages the blood-brain barrier,promotes T cell and NK cell infiltration during the early stage of cerebral ischemia through various processes,but also play a neuroprotective role by promoting nerve regeneration and recruiting CD 169 macrophages to infiltrate the brain parenchyma during cerebral ischemic recovery.In addition,IFN-γ also plays a different role in cerebral ischemia complications:promoting the onset of early post-stroke depression and preventing stroke-associated pneumonia.This article focuses on the dual role of IFN-γ in cerebral ischemia and its clinical research progress to provide research basis for prevention and treatment of cerebral ischemia.
关键词
IFN-γ/脑缺血/神经损伤/神经保护Key words
IFN-γ/cerebral ischemia/nerve damage/neuroprotection引用本文复制引用
出版年
2024
NETL
NSTL
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