The role of HIF-1α in neonatal hypoxic ischemic brain damage
Neonatal hypoxic ischemic brain damage(HIBD)is the major cause of mortality and morbidity to the newborn in the perinatal period,which results from partially or completely ischemia and hypoxia to the brain of neonates and leads to brain injury.HIBD is highly lethal and disabling,and its pathogenesis is complicated and not completely clear.Hypoxia-inducible factor-1α(HIF-1α)is a key transcription factor regulating cellular adaptation to hypoxic environments.In HIBD,HIF-1α has both neuroprotective and neurotoxic effects,mainly related to the duration and degree of neonatal cerebral ischemia and hypoxia.The research evidence of HIF-1α in HIBD and downstream events,as well as the specific mechanisms are summarized and discussed in this review.
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