Research progress and prospects of spatial transcriptomic technology
Spatial transcriptomics provides spatially gene expression profiles in tissues via sequencing or imaging.Combined with algorithms for image analysis and modeling,spatial transcriptomics can offer the locations of genes and cell types in tissues.Here,we summarize the technical principles and data exploring methods of spatial transcriptomics.We divide the experiment technologies into three categories and describe their characteristics in detail and introduce the principle and application of various data exploring methods for pre-processing,basic bioinformation analysis,cell annotation and interpreting specific tissue microenvironment.Finally,we highlight the limitations and future development of spatial transcriptomics,hoping to provide assistance to researchers in basic medicine and molecular biology fields.
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