Methods and Databases for Identification of Orthologs
Orthologous genes are those derived from a common ancestor through speciation,and typically retain similar architecture and biological function.Because of rapid accumulation of genomic and transcriptomic sequence,automated identification of orthology can facilitate functional annotation,and studies on comparative and evolutionary genomics.The main methods of orthologs prediction and corresponding databases constructed with these methods were briefly reviewed here.These methods can be grouped into three kinds,the first is similarity-based method,it has high sensibility and fast speed; the second is tree-based method,it is precise and informative; the third is hybrid method,it is the optimal trade-off between precision and sensibility.Finally the problems faced by the recognition process were summarized.
国家科技期刊平台
NSTL
万方数据
维普
