Research Progress of m6A Modification Regulating Autophagy in Male Reproductive Diseases
N6-M ethyl adenosine(m6A)modification is methylation of adenosine nucleotides at the N6 position in RNA molecules.It plays a pivotal role in various pathways of RNA metabolism such as mRNA splicing,translation,transportation,and degradation,widely affecting life processes.Autophagy is a natural process in which eukaryotic cells use lysosomes to degrade cytoplasmic proteins and damaged organelles under the regu-lation of autophagy-related genes.Herein,the research progress of m6A modification in regulating autophagy in the occurrence and development of male reproductive diseases was summarized.It aimed to provide refe-rence materials for studing the regulatory mechanisms of male reproduction through autophagy level regula-tion by m6A modification,and offer novel therapeutic strategies for treatment of male reproductive diseases.
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