首页|CARM1在恶性肿瘤中的作用与机制研究进展

CARM1在恶性肿瘤中的作用与机制研究进展

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共激活蛋白相关的精氨酸甲基转移酶1(coactivator-associated arginine methyltransferase 1,CARM1)是蛋白质精氨酸甲基转移酶(protein arginine methyltransferase,PRMT)家族的成员,又称PRMT4.近年来,CARM1作为一种辅助转录调节因子已被广泛研究,并被发现在肿瘤、炎性疾病、糖尿病等疾病中具有重要作用.一方面,CARM1通过调节翻译后甲基化修饰参与表观遗传调控,另一方面通过RNA代谢、代谢重编程等形式调控基因表达过程.随着研究的深入,CARM1在恶性肿瘤中的调控作用及分子机制逐步被揭示,但其在不同肿瘤中的调控效应不尽相同,目前需进一步探索其在恶性肿瘤中的调控网络机制.本文就近年来恶性肿瘤中CARM1的作用及其分子机制展开综述,以期为今后的研究提供新思路.
Research Progress on the Role and Molecular Mechanism of CARM1 in Malignant Tumors
Coactivator-associated arginine methyltransferase 1(CARM1)is a member of the protein arginine methyltransferase(PRMT)family,also known as PRMT4.In recent years,CARM1 has been widely studied as an auxiliary transcriptional regulator,and found to play an important role in the occurrence and develop-ment of various diseases such as tumors,inflammatory diseases and diabetes.It participates not only in epi-genetic regulation by regulating post-translational methylation modification,but also in gene expression regu-lation through RNA metabolism and metabolic reprogramming.In-depth studies have revealed the regulatory role and molecular mechanism of CARM1 in malignant tumors and showed that its regulatory effects in dif-ferent tumors are not the same.It is still necessary to explore its role in regulatory networks in malignant tumors.Herein,the role and molecular mechanism of CARM1 in malignant tumors were reviewed,with a hope of providing new ideas for related research.

coactivator-associated arginine methyltransferase 1(CARM1)malignant tumormethylation mo-dification

刘树义、马泽方、肖洒雨、高璐、曹明琪、陈子溦、张旭东、李瑜、赵婷婷

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西安医学院临床医学院,中国陕西西安 710021

西安医学院第二附属医院耳鼻咽喉头颈外科,中国陕西西安 710038

西安交通大学附属第二医院门诊部,中国陕西西安 710004

共激活蛋白相关的精氨酸甲基转移酶1(CARM1) 恶性肿瘤 甲基化修饰

国家自然科学基金资助项目陕西省高校科协青年人才托举计划项目陕西省自然科学基础研究计划项目陕西省大学生创新创业训练计划项目西安医学院中尼友好拉吉姆实验室开放基金项目

320008082020031423JK0649S202211840067省级121522067校级18LJM08

2024

10.16605/j.cnki.1007-7847.2023.06.0170

生命科学研究
湖南师范大学

生命科学研究

CSTPCD
影响因子：0.421
ISSN：1007-7847
年,卷(期)：2024.28(4)