首页|沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭的疗效及对NT-proBNP的影响

沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭的疗效及对NT-proBNP的影响

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目的 探讨沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭的疗效及对NT-proBNP的影响.方法 选取2022年4月至2023年5月云南省昆明市第一人民医院心内科收治的150例心力衰竭患者为研究对象,根据就诊时间分为两组.参照组采用沙库巴曲缬沙坦治疗,实验组在参照组基础上使用冻干重组人脑利钠肽治疗.对比两组治疗效果、心功能、血浆BNP、NT-proBNP水平及不良反应发生情况.结果 实验组治疗总有效率高于参照组,差异有统计学意义(P<0.05).实验组干预后心率低于参照组,每搏量及LVEF均高于参照组,差异有统计学意义(P<0.05).实验组干预后血浆BNP、NT-proBNP水平均低于参照组,差异有统计学意义(P<0.05).实验组不良反应发生率低于参照组,差异有统计学意义(P<0.05).结论 沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭可显著提高疗效,降低血浆BNP及NT-proBNP水平,改善患者心功能,减少不良反应.
Efficacy of Shakubatroxobin Combined with Freeze-dried Recombinant Human Brain Natriuretic Peptide in the Treatment of Heart Failure and Its Influence on NT-proBNP
Objective:To investigate the curative effect of shakubatravalsartan combined with freeze-dried recombi-nant human brain natriuretic peptide on heart failure and its influence on NT-proBNP.Methods:150 patients with heart failure admitted to the Department of Cardiology,First People's Hospital of Kunming City,Yunnan Province from April 2022 to May 2023 were selected as the research object,and were divided into two groups according to the time of treatment.The reference group was treated with shakubatravalsartan,and the experimental group was trea-ted with freeze-dried recombinant human brain natriuretic peptide on the basis of the reference group.The thera-peutic effect,cardiac function,plasma BNP、NT-proBNP levels and adverse reactions were compared between the two groups.Results:The total effective rate in the experimental group was higher than that in the reference group,and the difference was statistically significant(P<0.05).After intervention,the heart rate of the experimental group was lower than that of the reference group,and the stroke volume and LVEF were higher than those of the reference group,with statistical significance(P<0.05).The levels of plasma BNP and NT-proBNP in the experi-mental group were lower than those in the reference group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in experimental group was lower than that in reference group,and the difference was statistically significant(P<0.05).Conclusion:Shakubatrivalsartan combined with freeze-dried re-combinant human brain natriuretic peptide can significantly improve the curative effect,reduce the levels of plasma BNP and NT-proBNP,improve patients'cardiac function and reduce adverse reactions.

ShakubatrivalsartanFreeze-dried recombinant human brain natriuretic peptideHeart failureNT-proBNP

陈吉丽、王艳飞、吕彩萍

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云南省昆明市第一人民医院心内科,云南昆明 650100

沙库巴曲缬沙坦 冻干重组人脑利钠肽 心力衰竭 NT-proBNP

2024

生命科学仪器
北京市北分仪器技术公司

生命科学仪器

影响因子:0.305
ISSN:1671-7929
年,卷(期):2024.22(1)
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