富马酸丙酚替诺福韦对HBV感染免疫耐受期孕妇母婴阻断效果及安全性评价
Evaluation of the Maternal And Infant Blockade Effect And Safety of Propofol Tenofovir Fumarate on HBV Infection in Immunotolerant Pregnant Women
张丽媛 1符芳翔 2郑小静 1李娟 2杜永国1
作者信息
- 1. 海南医学院第二附属医院感染科,海南海口 570311
- 2. 海南医学院第二附属医院生殖医学科,海南海口 570311
- 折叠
摘要
目的 研究富马酸丙酚替诺福韦对乙型肝炎病毒(HBV)感染免疫耐受期孕妇的母婴阻断效果及安全性.方法 选取 2021 年 1 月至 2023 年 1 月在海南医学院第二附属医院诊治的 28 例 HBV感染免疫耐受期孕妇,根据抗病毒方案分为富马酸替诺福韦二吡呋酯(TDF)组和富马酸丙酚替诺福韦(TAF)组.对比两组 HBV DNA载量、肾小球滤过率(eGFR)、尿β2 微球蛋白及不良反应发生率.结果 两组治疗后 HBV DNA 较治疗前下降,P<0.05;两组治疗后eGFR与治疗前对比,P>0.05;治疗后TDF组尿β2 微球蛋白较治疗前明显升高,且高于TAF组,P<0.05.两组不良反应发生率对比,P>0.05.两组新生儿 HBV DNA、HBsAg 和 HBeAg 检测结果均为阴性.结论 对HBV感染免疫耐受期孕妇采用富马酸丙酚替诺福韦治疗的效果显著,可有效降低其 HBV DNA载量,获得良好的母婴阻断效果,且对肾脏的安全性良好.
Abstract
Objective:To Objective To study the blocking effect and safety of propofol fumarate on pregnant women infected with hepatitis B virus(HBV)in immune tolerance period.Methods:From January 2021 to January 2023,28 pregnant women with HBV infection in immune tolerance period were selected and divided into tenofovir dipiv-oxil fumarate(TDF)group and tenofovir dipivoxil fumarate(TAF)group according to the antiviral scheme.HBV DNA load,glomerular filtration rate(eGFR)、urinary β2 microglobulin and the incidence of adverse reactions were compared between the two groups.Results:HBV DNA in the two groups decreased after treatment compared with that before treatment,P<0.05;The eGFR of the two groups after treatment was compared with that before treat-ment,P>0.05;After treatment,urine β2 microglobulin in TDF group was significantly higher than that before treatment,and it was higher than that in TAF group,P<0.05.The incidence of adverse reactions between the two groups was compared,P>0.05.The detection results of HBV DNA、HBsAg and HBeAg in newborns of both groups were negative.Conclusion:Propofovir fumarate is effective in the treatment of pregnant women with immune tolerance to HBV infection,which can effectively reduce their HBV DNA,obtain a good mother-to-child bloc-king effect,and is safe for pregnant women's kidneys.
关键词
乙型肝炎病毒感染/耐受期孕妇/富马酸丙酚替诺福韦/母婴阻断Key words
Hepatitis B virus/Pregnant women during the tolerance period/Propofol tenofovir fumarate/Maternal and infant blockade引用本文复制引用
基金项目
海南省卫生健康行业科研项目(21A200262)
出版年
2024
国家科技期刊平台
NSTL
万方数据