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多模态神经电生理指标对意识障碍的预后评估价值

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目的 探讨多模态神经电生理指标联合检测对意识障碍患者预后评估的价值.方法 收集 2019 年 1 月至2023 年 12 月期间粤北人民医院收治的 48 例不同程度意识障碍患者为研究对象,所有患者均采取多模态神经电生理检查,依据检查结果将其划分为不同的等级.运用二元 Logistic 回归分析法建立回归模型,并绘制模型对应的ROC曲线,判断模型在患者预后评估中的应用价值.结果 单因素分析发现,两组患者脑电图分级、体感诱发电位分级、脑干听觉诱发电位分级、视觉诱发电位分级和事件相关电位分级对比,P<0.05.Logistic 回归分析发现,EEG与患者预后的相关性最强(OR=46.739,P=0.007),BAEP 等级(OR=22.737,P=0.036)及 SEP 等级(OR=26.513,P=0.039)次之.绘制 ROC 曲线发现,联合三种电生理方法所对应的 AUC 值最高,为 0.957(P=0.000).结论 EEG、BAEP、SEP均与意识障碍患者的预后存在相关性,可为临床进行预后评估提供科学参考;而且采用三种方法联合检测的准确率更高,值得在临床应用.
Prognostic value of multimodal neuroelectrophysiological indexes in consciousness disorders
Objective:To evaluate the prognostic value of multi-mode neuroelectrophysiological index combined de-tection in patients with consciousness disorder.Methods:48 patients with varying degrees of consciousness disorders admitted to Guangdong North People's Hospital from January 2019 to December 2023 were collected as the research subjects.All patients underwent multimodal neurophysiological examinations and were classified into different levels based on the examination results.Establish a regression model using binary logistic regression analysis and plot the corresponding ROC curve to assess the application value of the model in patient prognosis evaluation..Re-sults:Univariate analysis revealed that the EEG grading,somatosensory evoked potential grading,brainstem audi-tory evoked potential grading,visual evoked potential grading,and event-related potential grading were compared between the two groups of patients,with P<0.05.Logistic regression analysis showed that EEG had the strongest correlation with patient prognosis(OR=46.739,P=0.007),followed by BAEP grade(OR=22.737,P=0.036)and SEP grade(OR=26.513,P=0.039).By plotting the ROC curve,it was found that the AUC value corre-sponding to the combination of three electrophysiological methods was the highest,at 0.957(P=0.000).Conclu-sion:EEG、BAEP and SEP are correlated with the prognosis of patients with consciousness disorders,which provides a great reference value for evaluating the prognosis.The accuracy of the combined detection of the three methods is higher,and it is more worthy of clinical application.

Disorders of consciousnessElectroencephalogramPrognosisNeuroelectrophysiological indicators

王瑾、陈道朋、冯应君、刘泽宇、周礼鑫、周素芸

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粤北人民医院,广东韶关 512026

意识障碍 预后 脑电图 神经电生理指标

广东省韶关市卫生健康科研项目

Y22092

2024

生命科学仪器
北京市北分仪器技术公司

生命科学仪器

影响因子:0.305
ISSN:1671-7929
年,卷(期):2024.22(3)
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