The Predictive Value of Serum Retinol-Binding Protein Combined with Cystatin C in the Event of Progressive Renal Decline after Renal Transplantation
Objective:To explore the predictive value of serum retinol-binding protein(sRBP)combined with ser-um cystatin C(sCysC)in the progressive renal failure after renal transplantation.Methods:Sixty-eight renal trans-plant patients admitted to the First Affiliated Hospital of China University of Science and Technology from June 2017 to March 2023 were retrospectively included as the research object.Patients were divided into event group(n=31)and non-event group(n=37)according to whether progressive renal failure occurred from 3 months after operation to the end of the study.The baseline data sRBP and sCysC levels were compared between the two groups.Single factor and logistic regression model were used to analyze the relationship between related indexes and progressive renal failure,and ROC curve was used to analyze the predictive value of sRBP and sCysC for this e-vent.Results:Compared with the non-event group,the source of cadaveric kidney in the event group was more,and the levels of sRBP and sCysC were higher,P＜0.05.Logistic regression analysis showed that sRBP(or:1.069)and sCYSC(or:27.900)were independent risk factors for progressive renal failure(P＜0.05).ROC curve analysis shows that the area under the curve of sRBP combined with sCysC for predicting progressive renal failure events is 0.918(95％CI:0.841～0.995),the sensitivity is 90.3％,the specificity is 86.5％,and the best cutoff value is 0.390.Conclusion:sRBP and sCysC are independent risk factors for progressive renal failure.The combined detec-tion of sRBP and sCysC has important predictive value for progressive renal dysfunction after renal transplantation.
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