Study on the Changes of Lymphocyte Subpopulations And Cytokines in Asthmatic Children Infected with Mycoplasma Pneumoniae
Objective:To investigate the changes of lymphocyte subsets and cytokines in wheezing children infected by Mycoplasma pneumoniae(MP).Methods:From February 2021 to February 2023,45 children with non-asth-matic mycoplasma pneumonia(MPP)and 45 children with asthmatic MPP(observation group A)were selected from the General Hospital of Ningxia Medical University.At the same time,30 healthy children were selected as the control group.The levels of T lymphocytes(CD3+、CD4+、CD8+),natural killer(NK)cells(CD16+56+)、B lymphocytes(CD19+)and cytokines were compared among the three groups.Results:The levels of BCD4+and NK cells in observation group A and observation group A were lower than those in control group,and the levels of CD4+and NK cells in observation group B were lower than those in observation group A,P＜0.05.The levels of CD8+and CD19+cells in the observation group were higher than those in the control group,while those in the ob-servation group B were higher than those in the observation group A,P＜0.05.The levels of IL-4、IL-17 and TNF-α in children in observation group B were significantly higher than those in observation group A,and the lev-el of IL-10 was significantly lower than that in observation group A,P＜0.05.Conclusion:There is lymphocyte dysfunction in MPP wheezing children,which is manifested by the decrease of CD4+T cells,the increase of CD8+T cells and the decrease of NK cells.Moreover,the levels of IL-4、IL-17 and TNF-α increased,and the level of IL-10 decreased,all of which can lead to low immune function.
国家科技期刊平台
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