Based on Pharmacological Analysis the Inhibitory Effect And Potential Effect of Danzikang Knee Mixture on the Inflammatory Response of Knee Osteoarthritis were Analyzed
Objective:To pharmacologically analyze the inhibitory effect and potential effect of Danzikang knee mix-ture on the inflammatory response of knee osteoarthritis.Methods:The chemical components of Danzikang knee mixture were searched in the TCMSP database,and the active ingredients were selected to obtain potential targets.The Genecards database was used to search for target genes for knee osteoarthritis.The compounds were compared and integrated with the disease targets,and the GO and KEGG enrichment analysis of"Danzikang Knee Powder-Target-Disease-Gene"was carried out.Results:Danzikang knee mixture contained 398 components,correspond-ing to 6428 gene targets.After screening,296 key targets were obtained.Venn analysis showed that there were 140 intersecting targets associated with KO A disease.These targets involve nourishing the liver and kidney、invigorat-ing blood and removing blood stasis、dispelling cold and dampness,etc.,with a total of 1967 potential targets.Con-clusion:Danzikang knee mixture can slow down the degenerative changes of KOA cartilage tissue,promote the re-pair and regeneration of chondrocytes,and inhibit the production of inflammatory cytokines,which provides new ide-as and theoretical basis for the treatment of cartilage injury in traditional Chinese medicine,and has important social significance in clinical application.
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