Relationship between Serum Monocyte Chemoattractant Protein-1 And Interleukin-6 And Glucose Metabolism in Patients with Diabetes Nephropathy
Objective:To explore the relationship between serum monocyte chemoattractant protein-1(MCP-1)、interleukin(IL)-6 and glucose metabolism in patients with diabetes nephropathy(DN),so as to provide reference for the diagnosis and treatment of DN.Methods:A total of 145 T2DM patients admitted to our hospital from Janu-ary 2022 to February 2023 were collected.According to whether DN occurred,there were 90 cases in the simple T2DM group,30 cases in the early DN group,and 25 cases in the clinical DN group.The levels of serum MCP-1、IL-6 and glucose metabolism indexes in each group were compared,and the relationship between serum MCP-1、IL-6 and glucose metabolism indexes in DN patients was analyzed.Results:The levels of MCP-1、IL-6、FBP、HbA1c、FINS and HOMA-IR in clinical DN group and early DN group were significantly higher than those in T2DM group,P＜0.05.The levels of MCP-1、IL-6、FBP、HbA1c、FINS and HOMA-IR in clinical DN group were significantly higher than those in early DN group,P＜0.05.Linear correlation analysis showed that serum MCP-1 and IL-6 levels in DN patients were positively correlated with FBP、HbA1c、FINS and HOMA-IR(P＜0.05).Conclusion:The levels of serum MCP-1 and IL-6 in DN patients were positively correlated with their glu-cose metabolism disorders.In clinical practice,the level of serum MCP-1 and IL-6 in diabetes patients can be measured to assess their glucose metabolism disorders.
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