Correlation between Intestinal Flora Imbalance And Nonalcoholic Fatty Liver Disease
Objective:To explore and analyze the correlation between intestinal flora imbalance and nonalcoholic fatty liver(NAFLD),and to provide reference for early prevention of NAFLD.Methods:Forty-five patients with NAFLD admitted to the Physical Examination Center of Hainan Provincial People's Hospital from January 2021 to December 2022 were enrolled as NAFLD group,and 45 healthy people were enrolled as control group.The general data and blood biochemical metabolism indexes of the two groups were collected,and the intestinal flora was detec-ted by 16S rDNA method,and the clinical data and intestinal flora of the two groups were compared.Multivariate Logistic regression was used to analyze the relationship between intestinal flora imbalance and NAFLD.Results:The levels of ALT、AST、TG and LDL-C in NAFLD group were higher than those in control group,while HDL-C was lower than that in control group,P<0.05.The colony numbers of four intestinal flora in NAFLD group were higher than those in control group,P<0.05.The proportion of intestinal flora imbalance in NAFLD group was 51.11%,which was higher than that in control group(15.56%,P<0.05).Multivariate Logistic regression analysis showed that intestinal flora imbalance(OR=1.574)was an independent risk factor for NAFLD.Conclusion:There are significant differences in intestinal flora between NAFLD patients and healthy people.Intestinal flora disorder is an independent risk factor for NAFLD,which is of great significance to further study the pathological mechanism of NAFLD and formulate treatment and prevention strategies.
Non-alcoholic fatty liver diseaseGut microbiota dysbiosisBlood biochemical metabolic index
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