食品科学与人类健康(英文)2023，Vol.12Issue(6) ：2276-2285.DOI:10.1016/j.fshw.2023.03.047

Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice

Jie Li Yuanjie Guo Liyuan Ma Yixiang Liu Chao Zou Huiying Kuang Bing Han Yingliang Xiao Yanbo Wang
食品科学与人类健康(英文)2023，Vol.12Issue(6) ：2276-2285.DOI:10.1016/j.fshw.2023.03.047
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  • 维普
  • 万方数据

Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice

Jie Li 1Yuanjie Guo 1Liyuan Ma 1Yixiang Liu 2Chao Zou 3Huiying Kuang 1Bing Han 1Yingliang Xiao 1Yanbo Wang4
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作者信息

  • 1. College of Ocean Food and Biological Engineering,Xiamen Key Laboratory of Marine Functional Food,Fujian Provincial Engineering Technology Research Center of Marine Functional Food,Jimei University,Xiamen 361021,China
  • 2. College of Ocean Food and Biological Engineering,Xiamen Key Laboratory of Marine Functional Food,Fujian Provincial Engineering Technology Research Center of Marine Functional Food,Jimei University,Xiamen 361021,China;Collaborative Innovation Center of Provincial and Ministerial Co-construction for Marine Food Deep Processing,Dalian Polytechnic University,Dalian 116034,China
  • 3. Gaoan Public Inspection and Testing Center,Gaoan 330800,China
  • 4. College of Ocean Food and Biological Engineering,Xiamen Key Laboratory of Marine Functional Food,Fujian Provincial Engineering Technology Research Center of Marine Functional Food,Jimei University,Xiamen 361021,China;School of Food Science and Biotechnology,Zhejiang Gongshang University,Hangzhou 310018,China
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Abstract

Emerging evidence shows that dietary oligosaccharides are important prebiotics that can improve intestinal flora,while dietary polyphenols can act directly on intestinal cells.However,information about their synergistic effects on gut health is still limited.In this study,alginate oligosaccharide(AOS)and cyanidin-3-O-glucoside(C3G)were selected as a common marine plant oligosaccharide and terrestrial plant polyphenol,respectively,to study their effects on intestinal health.The results show that,in comparison to their individual applications,the combination of AOS and C3G(mass ratio,3:1)displayed a stronger ability to up-regulate the expression of tight junction proteins,while enhanced intestinal epithelial barrier was also observed and levels of mucin-2 and β-defensins were simultaneously increased in the intestinal mucus.Interestingly,the secretion of immunoglobulin A and immune-related cytokines were approximately doubled by the AOS+C3G mixture.In addition,the AOS+C3G mixture was found to be more conducive to the positive transformation of intestinal flora,which stimulated the growth of beneficial bacteria Akkermansia,Lachnospiraceae and Feacalibaculum while inhibiting the growth of harmful bacteria Helicobacter and Turicibacter.The data generated herein thus suggests that dietary oligosaccharides and dietary polyphenols may be more beneficial to intestinal health when applied in combination than their individual effects alone.

Key words

Alginate oligosaccharide/Cyanidin-3-O-glucoside/Prebiotics/Intestinal barrier function/Gut microbiota

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基金项目

国家重点研发计划(2019YFC1605003-3)

Fujian Science Foundation for Distinguished Young Scholars(2020J06024)

出版年

2023
食品科学与人类健康(英文)

食品科学与人类健康(英文)

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