Natural sources,refined extraction,biosynthesis,metabolism,and bioactivities of dietary polymethoxyflavones(PMFs)

Renyou Gan ¹Yi Liu ²Hang Li ²Yu Xi ²Huan Guo ²Fang Geng ³Qiguo Zhuang ⁴Huabin Li ⁵Dingtao Wu³

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作者信息

1. Research Center for Plants and Human Health,Institute of Urban Agriculture,Chinese Academy of Agricultural Sciences,Chengdu National Agricultural Science and Technology Center,Chengdu 610213,China;Key Laboratory of Coarse Cereal Processing,Ministry of Agriculture and Rural Affairs,Sichuan Engineering and Technology Research Centre of Coarse Cereal Industralization,School of Food and Biological Engineering,Chengdu University,Chengdu 610106,China
2. Research Center for Plants and Human Health,Institute of Urban Agriculture,Chinese Academy of Agricultural Sciences,Chengdu National Agricultural Science and Technology Center,Chengdu 610213,China
3. Key Laboratory of Coarse Cereal Processing,Ministry of Agriculture and Rural Affairs,Sichuan Engineering and Technology Research Centre of Coarse Cereal Industralization,School of Food and Biological Engineering,Chengdu University,Chengdu 610106,China
4. China-New Zealand Belt and Road Joint Laboratory on Kiwifruit,Sichuan Provincial Academy of Natural Resource Sciences,Chengdu 610213,China
5. Guangdong Provincial Key Laboratory of Food,Nutrition and Health,School of Public Health,Sun Yat-sen University,Guangzhou 510080,China
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Abstract

Polymethoxyflavones(PMFs)are a type of uncommon dietary flavonoids,characterized by more than one methoxy group,which exist in limited plant species,like Citrus species and Kaempferia parviflora.In addition,different PMFs,such as nobiletin,sinensetin,tangeretin,and casticin,have been isolated from these natural sources.PMFs have received increasing attention due to their multiple bioactivities,such as antioxidant,anti-inflammatory,anti-cancer,metabolic regulatory,immunoregulatory,neuroprotective,and skin protective effects.These bioactivities of PMFs should be associated with the regulation of critical molecular targets and the interaction with gut microbiota.In order to provide a comprehensive and updated review of PMFs,their natural sources,refined extraction,biosynthesis,metabolism,and bioactivities are summarised and discussed,with the emphasis on the molecular mechanisms of PMFs on regulating different chronic diseases.Overall,PMFs may be promising flavonoids to the forefront of nutraceuticals for the prevention and/or treatment of certain human chronic diseases.

Key words

Nobiletin/O-Methyltransferases/Gut microbiota/Bioactivities/Molecular mechanism

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基金项目

Local Financial Funds of National Agricultural Science and Technology Center,Chengdu,China(NASC2021KR01)

Agricultural Science and Technology Innovation Program(ASTIP-IUA-2022002)

出版年

2024

食品科学与人类健康(英文)

CSTPCDCSCD

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参考文献量136

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